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The Swiss Heroin Trial

Evan Thomas

ref:April 98 Heroinsight

As is the case with drugs in the Netherlands, the Swiss trial has been wide misrepresented or inadequately reported in the media. The following has been prepared using material from the Embassy of Switzerland, Families and Friends for Drug Law Reform (ACT) Inc., the Australian Parliamentary Group for Drug Law Reform and Dr Alex Wodak.

The Swiss trial was initiated following concern over increasing illicit drug use and the spread of AIDS, the incidence of which was the highest in Europe. In response, the authorities rapidly increased the availability of methadone treatment, and established needle exchanges, and made other changes to drug policy. In an environment of considerable local controversy and after two referendums, it was decided to conduct a national evaluation of prescription heroin and morphine. The main objectives were to improve public health, reduce public nuisance and attract drug users who had not previously been interested in treatment. The subjects selected had been users for an average of ten years, had histories of treatment and relapse and multiple severe social problems. Two-thirds had been treated for malnutrition; three quarters had hepatitis and a quarter were HIV positive.

The narcotics tested in the trial were morphine, methadone and heroin, for intravenous and oral use. The use of a cigarette form of heroin was also trialled.

Before the study was commenced, the research protocol and plan was submitted to the Ethics Committee of the Swiss Academy of Medical Sciences for approval. Other groups oversaw that the approved provisions and activities were observed and checked any side effects of the prescribed drugs.

At the request of the International Narcotics Control Board, the World Health Organisation appointed a research group to appraise the program and the results.

The research program involved two double-blind studies (the prescribed drug is not known to either the patient or the therapist], three randomised studies and 11 studies where the treatment is determined after discussion with the patient.

A total of 18 treatment centres were established: one was in a penal institution, the others were all outpatient clinics. 1146 patients effectively started treatment, however, by the end of 1996, 350 patients had dropped out of the study.

The Outcome

Social

  1. Homelessness declined from 15% to 3%

  2. Permanent employment improved from 14% to 32%

  3. Unemployment fell from 44% to 20%: the remainder lived on benefits or casual work or were occupied by home duties

  4. Debts during treatment were substantially reduced

  5. One third of patients who were welfare recipients on admission required no further support

  6. Other patients turned to welfare because they gave up dealing

  7. Originally only 13% of subjects were not involved in the drug scene. This increased to 44% during the trial, however, adequate fresh social contacts had not been made during the observation period

  8. Prostitution declined from 13% to 6%

Target Groups The program was able to reach those with a chronic heroin dependency, a history of failed treatment attempts and deficient health and social integration to a much greater extent than had been previously achieved with other programs. Patients on methadone programs who had previously continued to use illicit heroin were able to be admitted to the trial.

 

Health Status There was a significant reduction in general health problems over one and a half years, an improvement in nutrition, and fewer skin conditions Psychiatric conditions, in particular, depressive states regressed, as well as anxiety and delusional disorders Other conditions were monitored and referred to suitable medical treatment where appropriate

Other Dependencies

  1. Illicit heroin use rapidly and markedly regressed

  2. Daily cocaine use declined from 31% to 9%

  3. Benzodiazapine use decreased slowly

  4. Cannabis and alcohol consumption hardly declined at all

After 18 months, the continued regular use of cocaine (5%) and benzodiazepene (9%) proved to be a difficult problem to manage.

Criminal Activity

  • Income from illegal activity decreased to 10% from 69%

  • The number of offenders and offences declined by 60% during the first six months (source: police records and patients)

  • Convictions declined significantly (source: central criminal register)

Retention Rate After six months, the retention rate was 89%; after 18 months, it was 69%. Both these rates are above average compared to other programs. In some cases, the improvement in participants' health and social situation occurred early in the program; in others, after several months of treatment.

Drop-outs

  1. By the end of 1996, 83 people left the trial to commence abstinence therapy

  2. Of those who dropped out (excluding, of course, the above) more than 50% switched to another treatment

  3. Of the 1146 patients: 36 died, 17 attributable to AIDS and other infectious diseases

  4. Other causes of death included suicides, accidents and ODs of illicit narcotics

  5. There were no fatal ODs in the study itself

  6. The annual mortality rate in the trial of 1% is low compared to other studies of treatment of heroin dependants

Economics A cost-benefit evaluation of the trial showed a $45 benefit per patient per day. The greater part of the benefit flows from savings in criminal investigations and gaol costs, and by improvements in the health of the subjects.

Government Policy for Reducing Drug-related Problems This is four-pronged and described by the Swiss as: (i) repression; (ii) prevention; (iii) treatment; and (iv) harm reduction

On 28 September 1997, the people in Switzerland voted on an `initiative' intended to make the Swiss drug policy much more restrictive (the so-called heroin trial referendum). The initiative was rejected 71% to 30%. (Participation was 40% which is about average for Swiss referendums (voting is not compulsory).)

A number of prominent church leaders opposed the initiative including the Conference of Swiss Bishops and the Council of the Federation of Swiss Protestant Churches. Another referendum is proposed which, if passed, would liberalise Swiss narcotic drug laws.

The way the trial is currently structured suggests that it is not the program of the future, but it is a start in the right direction.

Dr Robert Haemmig, Psychiatrist, Medical Director, Drugs Branch,
University of Psychiatric Services, Berne, Switzerland.

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